What is nicotinamide mononucleotide NMN?

Nicotinamide mononucleotide, or NMN, is a naturally occurring compound in all living things. It is a ribonucleotide, which is a fundamental structural unit of RNA. This chemical is believed to promote a healthy aging process by preventing age-linked alteration in gene expression.

NMN might positively affect immune function and brain health and support healthy heart function. Certain studies also state how NMN can benefit animals’ liver and muscle tissue. [R]

Like all nucleotides, NMN comprises three components: a nitrogenous base, a sugar, and a phosphate group.

NMN supplement, unlike the majority of nucleotides, is used to synthesize nicotinamide adenine dinucleotide (NAD) and regulate energy balance.

The body produces NMN as an intermediate step or “precursor” to NAD. It is believed that an increase in NMN levels implies increased NAD levels.

NAD provides several noteworthy benefits. It boosts bodily energy production, balances the circadian rhythm, and facilitates hundreds of enzymatic reactions (support DNA repair), many of which delay the aging process. NAD levels, particularly the NAD+ form, naturally decline with age in many tissues.

Nicotinamide mononucleotide NMN is orally bioavailable in the laboratory studies done on it.

NMN for sale is a highly researched chemical, so selling this synthetic compound should only be for research. Any NMN supplement sold should not be used for human consumption.

Potential Applications of NMN

The following summarizes current animal and cell-based research that should guide future NMN research efforts. We want to emphasize that these studies should not be interpreted as evidence of any health benefit of NMN supplements.

As a research chemical, NMN should only be purchased for research purposes, not as a dietary supplement. The FDA does not approve NMN supplements.

Muscle well-being

Nicotinamide mononucleotide could also improve muscle tissue, leading to enhanced muscle strength.

According to Harvard University Professor David Sinclair, who has done extensive research on NMN, NMN supplementation aids muscle growth and recovery by improving blood and nutrient supply to the muscles. [R] [R]

NMN supplementation raises NAD+ levels, restoring endothelial cell growth and delivering oxygen and nutrients to muscle for recovery via the SIRT1 protein.

Healthy aging process

Telomeres are “tails” of DNA code that repeat at the ends of chromosomes. When a chromosome duplicates, some of its telomeres are lost; as a result, telomeres shorten with age, leading to cell death.

According to one study, NMN lengthened telomeres in mouse liver cells, which could lead to healthy aging. [R]

In mice, who received NMN supplementation, NMN increases the activity of sirtuins, a family of molecules involved in a complex anti-aging mechanism that scientists are only now beginning to understand. NMN is capable of increasing SIRT1 (sirtuin 1) gene activity. [R]

Sirtuins also protect cells from oxidative stress, DNA damage, and aging.

Low sirtuin levels have been linked to aging and diseases associated with aging, whereas high sirtuin levels improve female fertility. [R]

As we age, our NAD+ levels decrease, and more DBC1 binds to PARP1, preventing proper DNA repair. This process, however, can be accelerated by combining NMN with NAD+. [R]

The claim is supported by the findings of cells exposed to NMN supplements.

Metabolic syndrome

In a mouse study, an oral NMN supplement improved several health markers, including weight gain, energy metabolism, physical activity, fat profile, and eyesight. [R]

Because lab mice only lived for two years and the mice were followed for one year, this was a long-term study. Mice given a high nicotinamide mononucleotide NMN dose lost 18% of their body weight with no additional exercise (300 mg per kg of body weight per day).

Surprisingly, younger mice did not benefit; older mice were restored to a “younger” health profile, which could lend credence to the anti-aging capability of the NMN supplement.

Alzheimer’s disease

Researchers discovered that nicotinamide mononucleotide NMN reversed the effects of Alzheimer’s disease in mice. [R]

Researchers linked nicotinamide mononucleotide NMN to improved age-related diseases in animal models by increasing nicotinamide adenine dinucleotide (NAD+) levels in cells.

The lab-controlled NMN supplement improved not only cognitive function in Alzheimer’s disease-affected mice but also reduced toxic protein production in the brain and the inflammatory response associated with the disease.

Kidney

NMN may also benefit a specific organ of the human body, the kidney.

Another study discovered that giving elderly animal subjects an oral NMN supplement improved kidney function and prevented kidney damage. [R]

Increased NAD and SIRT1, which activate anti-aging and anti-inflammatory pathways, are most likely to blame.

Heart health

Blood vessel endothelium is frequently a target of oxidative damage, which includes the buildup of free radicals and reactive oxygen species (ROS). These harmful molecules contribute to plaque buildup because oxidized cholesterol particles cause arterial plaque. Furthermore, high levels of ROS reduce the availability of nitric oxide, which dilates blood vessels and maintains healthy blood pressure.

There are, however, ways to reduce cellular stress. Clinical trials for nicotinamide mononucleotide supplement, previously reported in Aging Cell, show that the chemical significantly reduced levels of an oxidative compound known as superoxide while increasing nitric oxide production in older mice. [R]

According to a January 2019 review published in Antioxidants & Redox Signaling, the sirtuin SIRT1 acts as a sensor for ROS, which can offer cardioprotection by inducing oxidative cell death. Supplementing NMN to SIRT1 and converting it to NAD+ may activate this oxidative sensor. [R]

Diabetes

Researchers at Washington University School of Medicine in St. Louis fed the natural compound nicotinamide mononucleotide (NMN) to mice to reverse diet- and age-induced diabetes.

According to the study published in Cell Metabolism, taking NMN as a dietary supplement could one day be used as an intervention or prevention for type 2 diabetes. [R]

Eye and bone health

A particular study resulted in the capability of NMN to enhance eye survival under dry eye conditions. [R]

The researchers discovered that NMN treatment prevented hyperosmotic stress-induced cell death. These findings suggest that NMN has a significant protective effect on eye cells in dry eye disease-like conditions.

Researchers studying NMN discovered that by stimulating a group of stem cells to differentiate into bone cells rather than fat cells, the molecule could promote bone density in mice. The method, described in the journal Cell Death & Disease, identifies NMN as a novel potential osteoporosis intervention. [R]

Mechanisms of Action

NMN has been shown to increase nicotinamide adenine dinucleotide (NAD+), an essential molecule that plays critical roles in over 400 metabolic reactions. NAD+ levels have been linked to age-related conditions in animals such as mice and rats, as well as humans, but increasing NAD+ with NMN alleviates these symptoms.

Adverse Reactions to Nicotinamide Mononucleotide

One cause for concern is that because NMN promotes the formation of new blood vessels, it may also promote angiogenesis and increase blood flow to tumors. In theory, this could lead to tumor growth and resistance to treatment.

Furthermore, NAD is required to develop certain types of brain cancer. Increasing NAD through NMN supplementation could be dangerous in people at risk of these cancers. [R]

However, one study found that the effect of NMN on angiogenesis (the formation of new blood vessels) only restored the vascular health of elderly mice to that of normal young mice. There was no evidence of increased cancer risk in this or other long-term NMN animal studies. More research into its effects on cancer risk, on the other hand, is required. [R]

In general, the safety of NMN in humans is unknown. Animal studies show that no adverse reactions occur even at high doses over a long period.

Frequently Asked Questions

Is NMN nicotinamide mononucleotide safe?

NMN is still a research chemical, and its benefits to human health are still being studied. Although there are exciting findings in animal studies, using NMN supplements to treat, cure or prevent certain human conditions is inadvisable.

Where does nicotinamide mononucleotide NMN come from?

NMN is a naturally occurring compound from certain fruits and vegetables such as avocados, broccoli, cabbage, edamame, and cucumbers. Including these in your daily diet can help you get more NMN.

What can you stack with NMN?

NMN may be stacked with resveratrol. A particular research group discovered the benefit of these research chemicals working together. [R]

Where can you buy NMN?

Pure Rawz is an online site that is the best place to buy NMN.

To be the best research chemicals supplier, we provide reference materials with every product we sell. Each product comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.