Nicotinamide Mononucleotide (NMN)

Description

Nicotinamide Mononucleotide (NMN) Overview

Nicotinamide mononucleotide (NMN) is a nucleotide-derived compound that functions as a biochemical precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme involved in numerous cellular processes. NAD+ is present in virtually all living cells and participates in a wide range of metabolic and enzymatic reactions.

In laboratory research environments, NMN is investigated for its role in cellular metabolism, energy regulation, and NAD+ biosynthesis pathways. Due to its biochemical properties, NMN has become a subject of interest in studies exploring cellular signaling and metabolic regulation.

Chemical and Molecular Properties

PubChem CID	14180
Molecular Formula	C11H15N2O8P
Molecular Weight	334.22 g/mol
Synonyms	Nicotinamide ribotide 2KG6QX4W0V Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-, inner salt DTXSID50911152
IUPAC	[(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate
CAS	1094-61-7
Labeling	Research Use Only (RUO), not for human or animal consumption.
Chemical Structure Depiction
Purity	99% Purity
Classification	Research Use Only (RUO)
Storage Temperature	Store at controlled room temperature, typically between 15°C to 30°C (59°F to 86°F)

Mechanisms of Action

NMN is primarily studied for its ability to contribute to intracellular NAD+ biosynthesis.

NAD+ plays an essential role in numerous metabolic reactions, including those involving:

• Cellular energy production
• DNA repair processes
• Enzyme activation
• Cellular stress responses

By serving as a precursor molecule, NMN is investigated for how it influences NAD+ -dependent biochemical pathways in experimental models.

Potential Research Applications

Current scientific interest in nicotinamide mononucleotide (NMN) primarily centers on its role in cellular metabolism and NAD+ biosynthesis. The following areas summarize topics that have been explored in laboratory research.

• Cellular Energy Metabolism

NMN is frequently investigated for its involvement in metabolic pathways that regulate intracellular NAD+ production.

• Sirtuin and Enzyme Signaling Pathways

Laboratory studies often examine NMN in connection with NAD+ -dependent enzymes, including members of the sirtuin family.

• Cellular Stress and DNA Maintenance Mechanisms

NMN is also explored in studies focused on cellular responses to oxidative stress and DNA maintenance pathways.

• Metabolic Regulation Studies

In experimental animal models, researchers investigate how NMN influences metabolic signaling pathways, including those associated with energy balance and nutrient metabolism.

• Neurobiological Research

Certain preclinical studies explore NMN within the context of neuronal metabolism and cellular signaling in neural tissues.

• Cardiovascular and Vascular Biology Research

NMN has also been examined in laboratory models that study endothelial cell function, oxidative stress pathways, and vascular signaling mechanisms.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

References:

1. Gujar, A. D., Le, S., Mao, D. D., Dadey, D. Y. A., Turski, A., Sasaki, Y., Aum, D., Luo, J., Dahiya, S., Yuan, L., Rich, K. M., Milbrandt, J., Hallahan, D. E., Yano, H., Tran, D. D., & Kim, A. H. (2016). An NAD+ -dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma. Proceedings of the National Academy of Sciences, 113(51), E8247–E8256. https://doi.org/10.1073/pnas.1610921114
2. Song, J., Li, J., Yang, F., Ning, G., Zhen, L., Wu, L., Zheng, Y., Zhang, Q., Lin, D., Xie, C., & Peng, L. (2019). Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow. Cell Death and Disease, 10(5), 336. https://doi.org/10.1038/s41419-019-1569-2
3. Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Migaud, M. E., Apte, R. S., Uchida, K., Yoshino, J., & Imai, S. (2016). Long-Term administration of nicotinamide mononucleotide mitigates Age-Associated physiological decline in mice. Cell Metabolism, 24(6), 795–806. https://doi.org/10.1016/j.cmet.2016.09.013