EGCG Green Tea Extract Standardized to 98% + Polyphenols 60% – Product Information
Epigallocatechin gallate (EGCG) is a notable plant compound renowned for its potential to mitigate inflammation, promote weight loss, and could contribute to the prevention of heart and brain diseases. The alleged effects are incorporated into green tea extract.
|EGCG Standardized to 98% + Polyphenols 60%|
|Molar Mass||458.372 g/mol|
|IUPAC Name||[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate|
What is EGCG Green Tea Extract Powder Standardized to 98% Polyphenols 60%?
Epigallocatechin gallate (EGCG), belongs to the category of green tea catechins, a group of plant-based compounds recognized as polyphenols. This chemical is usually found in camellia sinensis leaves.
These catechins, including EGCG, exhibit remarkable antioxidant properties, effectively safeguarding against cellular damage induced by free radicals.
Free radicals, highly reactive particles formed within the body, can inflict harm to cells when their levels become excessive. By incorporating antioxidant-rich foods like catechins into your diet, you can help minimize the detrimental effects of free radicals.
Moreover, extensive research suggests that catechins, such as EGCG, possess anti-inflammatory properties and offer protection against various chronic conditions, encompassing heart disease, diabetes, and specific types of cancer.
While EGCG occurs naturally in various plant-based foods, it is also obtainable as a dietary supplement, typically in the form of powdered extract. This chemical may also exist in pure form and some sellers offer gluten-free.
Many are confusing this product as a green tea extract supplement, although EGCG green tea extract is not an approved form of medication.
Possible Applications of EGCG Green Tea Extract Powder Standardized to 98% Polyphenols 60%
An insightful meta-analysis involving 9 studies and nearly 260,000 participants revealed a compelling association between green tea consumption and a decreased risk of heart disease. Notably, the alleged consumption of green tea supplements was found to be dose-dependent, meaning that higher intake correlated with a reduced incidence of heart attacks. Additionally, consuming more than 10 cups of green tea per day was linked to lower levels of LDL cholesterol, often referred to as “bad” cholesterol. Another meta-analysis identified flavonols present in green tea as protective compounds, further supporting its beneficial effects. [R][R]
The protective impact of green tea on cardiovascular health primarily stems from its ability to lower blood pressure and improve the profile of blood fats. Multiple meta-analyses of clinical trials have consistently demonstrated that drinking green tea leads to reductions in blood pressure, as well as total cholesterol and LDL cholesterol levels. [R][R][R]
In 2006, the U.S. Food and Drug Administration (FDA) granted approval to a topical ointment containing green tea extract known as Polyphenon E or Sinecatechins for the treatment of genital and anal warts. This approval came following rigorous evaluation in four clinical trials involving a substantial cohort of over 2,200 individuals, where the ointment demonstrated both efficacy and favorable tolerability. [R][R][R]
Two comprehensive studies encompassing a population of over 350,000 elderly individuals in Japan revealed a compelling association between higher green tea consumption and reduced mortality rates across various causes. Specifically, drinking more than 3 cups of green tea per day was linked to lower rates of death from all causes, including heart disease, stroke, respiratory diseases (in both genders), and cancer (in women). [R][R]
Furthermore, an additional study conducted on a cohort of over 14,000 Japanese elderly participants demonstrated a remarkably 76% lower mortality rate during a 6-year follow-up period among those who regularly consumed green tea. This significant decrease in mortality was observed for all causes of death and specifically for heart disease, with the added benefit of a reduced incidence of colorectal cancer. [R]
In cell-based studies, the presence of antioxidant polyphenols in green tea exhibited a protective effect on telomeres, the protective caps at the end of chromosomes, preventing their shortening. This finding suggests that the polyphenols in green tea may have the potential to contribute to increased longevity. [R]
Oxidative damage is known to be a potential catalyst for the development of various types of cancer. In this context, the abundant presence of powerful antioxidants in green tea makes it a promising candidate for cancer prevention. [R]
An observational study conducted on nearly 70,000 Chinese test subjects demonstrated a notable association between regular green tea consumption and a reduced incidence of colorectal cancer. This finding suggests that incorporating green tea into one’s routine may contribute to a lower risk of developing colorectal cancer. [R]
Similarly, a study involving over 4,000 French women found that the consumption of green tea, along with other antioxidant-rich beverages, was associated with a decreased occurrence of breast cancer. However, it’s worth noting that a separate study involving over 1,500 women did not establish a clear association between regular green tea intake and breast cancer risk. [R]
Clinical trials involving 225 test subjects have demonstrated the effectiveness of mouth rinses containing green tea extract in reducing plaque accumulation, gum inflammation, and the presence of harmful microbes known to contribute to cavities and gum disease. Specifically, the counts of Streptococcus mutants and lactobacilli, which are associated with these oral conditions, were significantly reduced with the use of green tea extract mouth rinses. [R][R]
Furthermore, laboratory studies conducted in test tubes have revealed that green tea extract exhibits inhibitory effects against bacteria responsible for cavities, namely S. mutans and S. salivarius. Moreover, the incorporation of epigallocatechin gallate, a key compound in green tea, into dental glue has been shown to effectively impede the growth of S. mutans. [R]
These findings highlight the potential of green tea extract, as well as its active component EGCG, in combatting oral health issues by reducing the growth of cavity-causing bacteria and promoting oral hygiene when used in mouth rinses or dental applications. [R]
Epigallocatechin gallate, caffeine, and L-theanine collectively offer promising benefits for brain function and overall brain health.
The presence of caffeine in green tea is significant enough to contribute to improvements in memory, reaction time, and the elevation of dopamine and norepinephrine levels in the brain. [R]
Notably, a clinical trial involving 12 healthy volunteers demonstrated that green tea extract enhanced brain activity in the dorsolateral prefrontal cortex, a key region involved in working memory processing. Furthermore, in another study comprising 8 healthy individuals, green tea consumption was found to increase overall brain activity, particularly in the theta wave frequency range, suggesting its potential to enhance alertness and attention. [R][R]
L-theanine, another component found in green tea, has been investigated in a separate trial involving 35 healthy participants. The study revealed that L-theanine supplementation notably increased alpha wave activity, which is associated with mental alertness and arousal. [R]
In a comprehensive meta-analysis encompassing 7 studies and over 286,000 laboratory participants, the consumption of possible green tea was linked to a significant 18% reduction in the incidence of type 2 diabetes. This suggests a potential protective effect against the development of this condition. [R]
However, the impact of green tea (Camellia Sinensis plant) on blood sugar control in test subjects with type 2 diabetes or those at risk of developing it is less conclusive. While two separate meta-analyses reported the effectiveness of green tea in reducing fasting blood sugar levels and one of them also showed a reduction in fasting insulin levels at higher doses, a third meta-analysis found green tea to be ineffective in lowering markers of type 2 diabetes in individuals at risk. [R][R]
These mixed findings suggest that further research is needed to fully understand the potential of green tea in improving blood sugar control and managing type 2 diabetes. While it may have some beneficial effects, the overall impact and effectiveness of green tea as a therapeutic intervention for individuals with type 2 diabetes or at risk of developing the condition require further investigation. [R]
Three comprehensive meta-analyses, collectively analyzing 44 studies, indicated that green tea and its catechins exerted a slight influence on weight loss. While the observed effects were not substantial, they still suggested a potential for promoting weight reduction. [R][R]
Furthermore, a meta-analysis involving 8 studies revealed that green tea catechins may facilitate weight loss by stimulating fat-burning and increasing energy expenditure. However, contrasting findings emerged from two additional meta-analyses encompassing 21 studies, which concluded that the fat-burning effects of green tea catechins are more pronounced when combined with caffeine. [R][R]
How Does EGCG Green Tea Extract Powder Standardized to 98% Polyphenols 60% Work
EGCG, a compound found in green tea, has been found to possess various beneficial properties that can impact cell behavior and signaling pathways. Studies have shown that EGCG can inhibit the activation of certain proteins involved in cell transformation, such as mitogen activated protein kinases and activator protein-1. It has also been observed to interfere with the phosphorylation (activation) of growth factor receptors like epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), and HER-2/neu. Additionally, EGCG has been found to arrest cells in the G0-G1 phase, induce programmed cell death (apoptosis), inhibit DNA methyltransferase activity, and disrupt abnormal arachidonic acid metabolism. One particular area of interest is EGCG’s ability to inhibit EGFR signaling, which is the focus of the current study.
Research by Liang et al. demonstrated that EGCG can inhibit the phosphorylation (activation) of EGFR in a cell line called A431. They also suggested that EGCG may prevent the binding of epidermal growth factor (EGF) to EGFR based on a ligand-binding assay. In in vitro kinase assays, EGCG was found to inhibit the activity of receptor tyrosine kinases, including EGFR, with an IC50 (concentration at which 50% inhibition occurs) of 1 to 2 μmol/L. Masuda et al. discovered that EGCG inhibits EGFR phosphorylation in two head and neck cancer cell lines, YCU-H891 and YCU-N861. They proposed that this inhibition of EGFR phosphorylation leads to the suppression of downstream events, including the phosphorylation of extracellular signal-regulated kinase, signal transducers, and activators of transcription 3, and Akt, ultimately resulting in the inhibition of cell growth.
Frequently Asked Questions
What is EGCG?
EGCG stands for Epigallocatechin Gallate, which is a potent antioxidant compound found in green tea extracts. It is known for its numerous health benefits and is one of the key polyphenols present in green tea leaves.
What is the significance of the 98% Polyphenols and 60% standardization in EGCG Green Tea Extract Powder?
The 98% Polyphenols specification indicates that the EGCG Green Tea Extract Powder is highly concentrated in polyphenols, which are beneficial plant compounds known for their antioxidant properties. The 60% standardization signifies that 60% of the extract’s content is specifically composed of EGCG, the primary active compound responsible for many of the health benefits associated with green tea.
What are the potential health benefits of EGCG Green Tea Extract Powder?
EGCG Green Tea Extract Powder has been linked to numerous potential health benefits. It is known for its antioxidant properties, which could help protect cells from damage caused by harmful free radicals. Additionally, it may support cardiovascular health, promote weight management, assist in maintaining healthy blood sugar levels, and contribute to overall well-being.
Where Can You Buy EGCG Green Tea Extract Powder Standardized to 98% Polyphenols 60% Online?
Pure Rawz is the best place to buy the highest-quality EGCG Green Tea Extract Powder Standardized to 98% Polyphenols 60% online. Our website contains EGCG Green Tea Extract Powder reviews from our customers.
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