Description

Selank – Product Information

Selank is a synthetic analog of Tuftsin. Clinical studies have shown that it produces anxiolytic effects comparable to that of medicines used to treat anxiety and insomnia. Selank has also been found to increase the effects of phenazepam (an anxiolytic drug) in anxiety patients.

In preclinical studies, Selank enhanced learning and memory, prevented weight gain, and enhanced antioxidant activity in the liver. Animals administered Selank also experienced improved blood flow and reduced blood pressure. Their blood and total cholesterol levels dipped.

PureRawz sells Selank for research and laboratory purposes only.

How does Selank Work?

Although its exact mechanism of action remains unknown, here are a few ways Selank is believed to act:

May Stabilize Enkephalins

Enkephalins are naturally occurring peptides with potent painkilling effects. A study on mice with different phenotypes of emotional and stress reactions showed that Selank treatment inhibited enkephalin degrading enzymes to stabilize enkephalin levels. [R]

Might Bind to GABA receptors

Results from two cell-based studies indicate that Selank may bind to GABA receptors. If proven in clinical studies, this would explain Selank’s potential anti-anxiety effects. As benzodiazepines (classical anti-anxiety medications) are also GABA receptor agonists. [R][R][R]

May Increase BDNF levels

Intranasal administration of Selank has been shown to stimulate an increase in brain-derived neurotrophic factor (BDNF) levels in the rat brain. BDNF is a key molecule that plays a vital role in learning and memory. This mechanism may help explain Selank’s claimed cognitive effects. [R][R]

Might Influence Neurotransmitter levels

In one rat study, Selank increased norepinephrine and reduced serotonin and dopamine levels. However, in another group of mice, Selank treatment didn’t change serotonin levels but reportedly increased dopamine and norepinephrine levels. Thus, its exact mechanism remains unknown. [R]

Selank Research

What follows is a summary of the existing clinical, animal, and cell-based research on Selank. The information presented in this section is for educational purposes only and shouldn’t be constituted medical advice. PureRawz doesn’t sell Selank for human consumption.

Selank and Anxiety

In a clinical trial involving 62 people, those administered Selank had reduced anxiety symptoms at the end of the study period. The effects of Selank were found to be similar to those of medazepam, an FDA-approved drug for the treatment of anxiety disorders. [R]

Another clinical trial investigated the anxiolytic effects of Selank in 60 patients with multiple anxiety disorders. Results indicated that Selank possesses pronounced anxiolytic effects. It was also shown that Selank treatment improved the patient’s quality of life. [R]

Furthermore, in one study of 70 patients, Selank reportedly increased the positive effects of phenazepam (an anti-anxiety drug used in some US states). At the same time, Selank was found to decrease the drug’s side effects, such as memory loss, sedation, sexual disturbances, etc. [R]

Various preclinical studies have also shed light on Selank’s potential anti-anxiety effects. In one animal study, 4 weeks of daily Selank treatment reduced anxiety in mice. Another study found that Selank’s anxiolytic effects were more pronounced in mice who were more anxious. [R][R]

Selank and Memory

A preclinical study investigated the effects of Selank treatment on the memory processes of rats. The animals were given either Selank or saline. Findings from the study suggest that Selank induces an increase in memory, especially when injected during the memory consolidation phase. [R]

One another animal study found that Selank treatment helped preserve memory in monkeys. The study further demonstrated that the anti-stress effects of Selank follow a different pathway than previously-studied neuro-hormones and have long-term compensatory character. [R]

However, clinical studies investigating the effects of Selank on memory are lacking.

Selank and Learning

One animal study compared the effects of Selank in rats with initially low levels of learning with those in normal rats. These experiments showed that Selank significantly activated the learning process in rats with initially poor learning ability. Plus, these effects increased with each dose. [R]

In another study, Selank-treated rats learned more quickly how to avoid an electrical shock than their counterparts who weren’t administered Selank peptide. Furthermore, the treatment group also exhibited fewer anxiety symptoms, highlighting the anxiolytic properties of this research chemical. [R]

Selank and Blood Flow

An animal study explored the potential effects of Selank treatment on blood pressure and blood flow in sedated cats. Findings from the study reveal that Selank increased cerebral blood flow by 24 +/- 2.8%. The drug also induced a 32 +/- 4.3% decrease in blood pressure. [R]

However, while Selank did induce positive changes in blood flow and blood pressure, those changes weren’t long-lasting. For instance, the increase in blood flow lasted for up to 10 minutes, with the reduction in blood pressure vanishing within 3 minutes.

Selank and Cholesterol

Results from an animal study indicate that rats fed a high-fat diet showed a 58% decrease in total cholesterol levels when treated with Selank. A 22% reduction in triglycerides accompanied this decrease in cholesterol levels. [R]

Additionally, rats fed a high-fat diet retained their initial weight throughout the treatment, with an average weight gain of only 6 grams. These data indicate that Selank administration affects the accumulation of fat mass in rats fed with a high-fat diet.

Selank and Immune Function

In a clinical trial involving patients with depression, Selank treatment reportedly increased IL-6 levels in the subjects’ blood cells. The increase in IL-6 levels was observed in patients who had taken Selank for two weeks. IL-6 is a protein that helps regulate immune responses. [R]

Aside from that, findings from one cell-based study highlight the potential anti-viral properties of Selank. The study showed that Selank induces the secretion of interferons. These anti-viral particles protect cell cultures from the cytopathological effects of viruses. [R]

Selank and Alcohol Withdrawal

To investigate its effects on alcohol withdrawal symptoms, rats who were given a 10% solution of ethanol as their sole drinking source for 6 months were treated with Selank. Tests conducted at the study end found that Selank eliminated anxiety induced by ethanol withdrawal. [R]

In addition to eliminating anxiety, Selank also eradicated mechanical allodynia induced by alcohol withdrawal. Mechanical allodynia is a symptom of alcohol withdrawal in which benign stimuli like light touch cause a painful sensation. If left untreated, it can facilitate relapse. [R]

Selank and Depression

A rat study was conducted to investigate the effects of Selank on symptoms of depression. High doses of Selank reportedly counteracted symptoms of depression in the behavior of rats. These results indicate the presence of an antidepressant component in the spectrum of Selank’s activity. [R]

Selank and Stress

Findings from an animal study revealed that the peptide, Selank, enhances the effect of diazepam in reducing anxiety in unpredictable chronic mild stress conditions in rats. It was also shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs. [R]

Frequently Asked Questions

Is Selank legal?

Selank is clinically used in Russia for the treatment of various conditions, particularly generalized anxiety disorder (GAD). However, it’s yet to be approved by the FDA.

Is Selank the same as Semax?

Semax and Selank are synthetic heptapeptides (i.e. seven amino acids long). However, while Semax is a synthetic analog of ACTH 4-10, the peptide anxiolytic Selank is an analog of Tuftsin. Plus, Semax (Met-Glu-His-Phe-Pro-Gly-Pro) and Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) have different amino acid sequences.

What is the half-life of Selank?

Selank has a relatively short half-life of 1-2 minutes.

Where to Buy Selank?

PureRawz is the best place to buy Selank online.

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Selank Summary

Various clinical trials have shown that Selank possesses anxiolytic effects. Preclinical studies have highlighted its potential ability to enhance learning and memory, fight depression, reduce blood and total cholesterol levels, and alleviate alcohol withdrawal symptoms. More clinical studies are needed to examine its safety and efficacy in humans.