What is Sunifiram?

Sunifiram (DM-235) is an AMPAkine drug (acts via AMPA receptors). It is a synthetic derivative of Piracetam and has a somewhat similar chemical structure. Still, despite having comparable anti-amnesic effects, Sunifiram is four times more potent than Piracetam. [R][R]

Sunifiram was originally developed to treat the symptoms of cognitive decline in Alzheimer’s disease patients. However, due to the lack of funding, no human trials were conducted to investigate its effects. All the evidence about its effects comes from animal studies. [R]

These preclinical studies show that Sunifiram is capable of enhancing memory and learning, reducing pain sensitivity, and affecting wakefulness and/or sleep.

Furthermore, it has been found that Sunifiram might reverse surgically-induced impairments in memory [R][R][R][R]

How Does Sunifiram Work?

Although its exact working mechanism remains unknown, Sunifiram has been shown to:

• Stimulate the release of acetylcholine. In one animal study, Sunifiram reportedly increased acetylcholine release. Another preclinical study showed it blocked the effects of scopolamine, a drug that blocks acetylcholine release. [R][R]
• Activate AMPA receptors. Results from a mice study suggest that Sunifiram activates the AMPA-mediated neurotransmission system. Plus, it may block AMPA receptor activation by drugs that suppress the activity of AMPA receptors. [R]
• Regulate glucose uptake. Authors of a cell-based study report that Sunifiram may increase glucose uptake at a lower dose and increase it at a mega dose. [R]
• Activate NDMA glutamate receptors. Two cell-based studies suggest how Sunifiram may activate NDMA glutamate receptors. That is, by promoting the release of the neurotransmitter glutamate, which is proven to bind to glutamate receptors. [R][R]

Sunifiram Research

Following is a summary of the existing clinical research on Sunifiram. The information given in this section is for educational purposes only and doesn’t constitute medical advice. Speak to a medical health professional to get a qualified Sunifiram review.

Sunifiram and Memory

A preclinical study has reported that Sunifiram partially reversed surgically-induced impairments in memory in mice. It also reduced long-term potentiation. LTP is one of the main mechanisms in synaptic plasticity and plays a vital role in the ability to acquire, encode, and store memories. [R]

Two animal studies reported that Sunifiram counteracted experimentally-induced memory impairments (amnesia) in mice caused by other drugs. These drugs included scopolamine, clonidine, baclofen, and mecamylamine. [R][R]

Sunifiram and Learning

In one animal study involving mice, small doses of Sunifiram (0.01 mg/kg of body weight) increased the rate at which mice learned how to avoid shocks. The enhanced learning ability was measured using a behavioral task referred to as the passive avoidance test. [R]

According to another animal study, Sunifiram dosing (0.1 mg/kg body weight) reportedly increased the rate at which mice learned how to recognize social partners after brief interactions.

This test measured the learning ability using a task called the behavioral learning test. [R]

Sunifiram and Pain Sensitivity

Only one animal study has investigated the effects of Sunifiram on pain sensitivity.

The study investigated how mice responded to heat-related pain after being administered Sunifiram. A medium dose of Sunifiram (0.01 mg/kg) was reported to induce a mild pain-blocking effect in the mice. However, at a high as well as at a low dose, much weaker effects were reported. [R]

Sunifiram and Wakefulness

Evidence from one mouse study indicated that Sunifiram may promote wakefulness. [R]

In the study, Sunifiram was reported to counteract the sleep-promoting effects of another drug. More specifically, animals treated with this research chemical slept less than their counterparts in the control group. [R]

Where to Buy Sunifiram?

PureRawz is the best place to buy the highest-quality Sunifiram online.

In order to be the best supplier of research chemicals, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin.

We sell Sunifiram powder and tablet formulations for laboratory and research purposes only.

Summary

Sunifiram is an experimental research chemical derived from Piracetam. It has significantly greater potency than Piracetam and has demonstrated the ability to reduce pain sensitivity, reverse memory impairments (amnesia), and enhance learning in animal studies.

However, due to the absence of human studies, Sunifiram hasn’t been approved by any country or regulatory agency globally. It is therefore unknown whether it could replicate the above effects in humans. PureRawz sells Sunifiram for laboratory and research use only.