Agmatine Sulfate

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Agmatine Sulfate – Product Information

  • Agmatine Sulfate is offered as 250mg per capsule for 60 capsules, totaling 15g.

Agmatine Sulfate is a natural compound formed from the amino acid L-Arginine, via the process of decarboxylation. As an experimental research compound, agmatine sulfate is being studied for several potential indications such as cardioprotection, diabetes, decreased kidney function, neuroprotection, and psychiatric conditions.

Agmatine Sulfate
CAS Number 2482-00-0
Molar Mass 228.27 g/mol
Chemical Formula C5H16N4O4S
IUPAC Name 2-(4-aminobutyl)guanidine;sulfuric acid

How does Agmatine Sulfate work?

As mentioned above, Agmatine is derived from L-Arginine through decarboxylation, a process by which a carboxylic acid group is removed. It is then potentially stored in neurons and could be released during neuronal activation.

As a result, Agmatine is considered to be a neurotransmitter and neuromodulator.

Agmatine has several potential mechanisms of action. Research shows it may have the potential ability to inhibit N-methyl-D-aspartate (NMDA) and nicotinic acetylcholine receptors, as well as activate imidazoline receptors. Agmatine may also inhibit nitric oxide synthase enzymes, which would allow it to potentially regulate elevated levels of nitric oxide. Agmatine may also potentially inhibit calcium channels and certain serotonin receptors.

Further research is needed to determine the full extent of agmatine’s mechanisms.

Agmatine Sulfate vs. L-Arginine

Agmatine is a metabolite of L-Arginine. In the body, the enzyme nitric oxide synthase (NOS) produces nitric oxide from the amino acid arginine, which is part of the urea cycle.

Agmatine Sulfate Research

The primary function of Agmatine sulfate is to potentially boost nitric oxide. In fact, research shows that Agmatine stimulated nitrite production three-fold above basal nitrite formation by endothelial cells. [R]

Most of the potential benefits associated with both L-Arginine and Agmatine Sulfate are due to the potential increase in nitric oxide. Below is some of the most relevant research into the potential agmatine sulfate benefits.

Agmatine Sulfate May Aid in Recovery

A recent study showed the potential effects of citrulline on fatigue and exercise performance in mice. This may be very relevant as citrulline is a precursor to L-Arginine which in itself is converted to Agmatine sulfate. The study found that the increase in nitric oxide production may potentially reduce muscle soreness. [R]

Agmatine Sulfate on a Cellular Level

A 2009 study found that Agmatine has the potential to protect mitochondrial function and confers resistance to cellular apoptosis. This alludes to the potential of agmatine sulfate as a future therapeutic tool. [R]

Agmatine Sulfate and Potential for Muscle Growth

Research shows that nitric oxide naturally supports vasodilation, an increase of NO in the muscles means better blood flow. This shows the potential in delivering more oxygen, coming from the increase of blood flow and nutrients to working muscles, and accelerating protein synthesis which may support and fuel muscle growth. [R]

Agmatine Sulfate and Erectile Dysfunction

A 2019 review of 10 studies found that utilizing arginine in doses ranging from 1.5 – 5 grams daily may have significantly improved erectile dysfunction compared to the non-treatment and placebo groups. [R] This alludes to the potential future research of Agmatine sulfate which is a by-product of L-Arginine.

Agmatine Sulfate and Pain Perception

According to several reports and studies, agmatine could potentially naturally reverse pain from factors like inflammation, neuropathy, and spinal cord injury. The substance helps to combat glutamate receptors to regulate pain perception. This means Agmatine Sulfate may potentially be able to offer similar short-term pain relief due to its stimulation of nitric oxide.

These findings were shown in a study on rodent models which demonstrated a unique anti-plasticity and neuroprotective role in processes underlying persistent pain and neuronal injury. [R]

Agmatine sulfate FAQs

Is Agmatine Sulfate Legal?

Agmatine sulfate is legal to buy as a research compound. However, it is not intended for human consumption or use as a dietary supplement.

Where to Buy Agmatine Sulfate Online

PureRawz is the best place to buy Agmatine Sulfate online.

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This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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2 reviews for Agmatine Sulfate

  1. Thomas Norman

    I couldn’t have asked for a better product; this one is really worth the price! overall feeling better and many symptoms disappearing. You guys really know how to look after your clients.

  2. Berwan

    Helps with circulation and exercise performance.

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