How Does GW501516 Work?

Cardarine selectively targets the peroxisome-activated receptor δ (PPARδ) with high affinity and potency, which is why it is termed a PPARδ agonist. PPARδ agonists are known to enhance fatty acid metabolism, preserving glucose and physical endurance. [R] [R]

Research has shown that this research compound regulates fatty acid oxidation in several tissues, such as the skeletal muscle tissue and adipose tissue. This shows immense promise in the potential ability of Cardarine to cause fat loss and offer additional benefits.

Cardarine Research

Multiple animal studies have been carried out on Cardarine. This PPAR Delta receptor agonist has also attracted a few clinical trials. However, the available clinical data isn’t sufficient to claim it is safe for human consumption. More clinical trials are needed to determine its long-term consequences.

Cardarine and Cholesterol

GW501516 (2.5, 5.0, or 10.0 mg) or placebo was given for 12 weeks to patients (n=268) with high-density lipoprotein (HDL) cholesterol <1.16 mmol/L. Fasting lipids/apolipoproteins (apos), insulin, glucose, and free fatty acid were measured; changes from baseline were calculated and assessed.

GW501516 demonstrated HDL cholesterol increases up to 16.9% (10 mg) and apoA-I increases up to 6.6%. Reductions were observed in low-density lipoprotein (LDL) cholesterol (-7.3%), triglycerides (-16.9%), apoB (-14.9%), and free fatty acids (-19.4%). [R]

A second smaller exploratory study assessed GW501516’s impact on lipoprotein particle concentration. Significant reductions in the concentration of very LDL (-19%), intermediate LDL (-52%), and LDL (-14%) were observed, whereas the number of HDL particles increased by 10%.

Cardarine and Fatty Acids

A small study was conducted on mice to assess the impact of PPAR delta agonists on fatty acids. It was found that GW501516 treatment induced fatty acid oxidation in mouse skeletal muscles.

Aside from that, Cardarine treatment also markedly improved diabetes. This was revealed by the decrease in plasma glucose and blood insulin levels in obese mice. These data suggest that GW501516 merits further investigation for its potential ability to induce fatty acid oxidation. [R]

Cardarine and Running Endurance

A study was carried out to assess the impact of GW501516 on running endurance in Kunming mice.

It was observed that this research compound enhanced running endurance in both trained and untrained mice. GW501516 treatment also increased the percentage of slow-twitch muscle fibres. [R]

Cardarine and Inflammation

A recent study set out to investigate the effects of GW501516 as a PPAR delta agonist on inflammation in mice. It was found that GW501516 treatment reduced atherosclerotic lesions. This data shows that Cardarine merits further investigation as a potential treatment for atherosclerosis. [R]

To further assess its anti-inflammatory activity, one study examined interleukin-6 levels, which we know to be a marker of inflammation. The results obtained showed that GW501516 might be useful for suppressing specific systemic inflammatory reactions. [R]

Cardarine and Metabolism

A study investigated the effects of GW501516 administration on metabolic disorders in Caucasian men (ages 18 – 15). It was observed that a two-week treatment with GW501516 ameliorated multiple metabolic abnormalities, including obesity, insulin resistance, and oxidative stress. [R]

Longer randomized trials and research could potentially evaluate its efficacy in improving physical function and health outcomes in select populations.

Cardarine FAQs

Is Cardarine A SARM?

Cardarine is not a selective androgen receptor modulator or SARM. SARMs work by binding androgen receptors in specific tissues, whereas GW501516 specifically targets the peroxisome-activated receptor δ (PPARδ).

Is Cardarine Legal?

Cardarine is legal to buy and sell as a research compound. It can be used for laboratory research purposes only.

What Is The Half-Life of Cardarine?

Cardarine has a half-life of between 12 and 24 hours.

Does GW501516 Increase Muscle Gene Expression?

Research has shown that Cardarine increases muscle gene expression, especially genes involved in preferential lipid utilization. This highlights its potential ability to enhance the cholesterol profile.

Where to Buy GW501516 Online

PureRawz is the best place to buy Cardarine online.

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Summary

Cardarine has demonstrated its ability to reduce inflammation, cause fatty acid oxidation, and improve cholesterol profile in animal studies. Long-term and randomized clinical trials are needed to evaluate its safety and efficacy in humans.

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