Cardarine (GW-501516) – Product Details
GW-501516, also known as Cardarine, is a PPAR agonist. Cardarine is used in research for its potential to facilitate fat-burning by increasing endurance and stamina.
A study done on the effects of GW-501516 for enhancing running endurance in Kunming mice demonstrated that a 3-week dosing protocol with GW-501516 was able to increase performance related to running of both trained and untrained mice.
Similar to training, GW-501516 showed an increase in mitochondrial fatty acid oxidation and enhanced fat metabolism in muscle tissue. This could potentially lead to less demanding cardiovascular work, increasing weekly deficits, and resulting in increased fat loss.
Another study found that when dosed to obese rhesus monkeys, GW-501516 caused a dramatic dose-dependent rise in high-density lipoprotein cholesterol while lowering the levels of low-density lipoprotein cholesterol, fasting triglycerides, and fasting insulin.
Cardarine | Â |
CAS Number | 317318-70-0 |
Molar Mass | 453.49 g·mol−1 |
Chemical Formula | C21H18F3NO3S2 |
IUPAC Name | {4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid |
How Does GW-501516 Work?
Cardarine selectively targets the peroxisome-activated receptor δ (PPARδ) with high affinity and potency, which is why it is termed a PPARδ agonist. PPARδ agonists are known to enhance fatty acid metabolism, preserving glucose and physical endurance. [R] [R]
Research has shown that this research compound regulates fatty acid oxidation in several tissues, such as the skeletal muscle tissue and adipose tissue. This shows immense promise in the potential ability of Cardarine to cause fat loss and offer additional benefits.
Cardarine Research
Multiple animal studies have been carried out on Cardarine. This PPAR Delta receptor agonist has also attracted a few clinical trials. However, the available clinical data isn’t sufficient to claim it is safe for human consumption. More clinical trials are needed to determine its long-term consequences.
Cardarine and Cholesterol
GW-501516 (2.5, 5.0, or 10.0 mg) or placebo was given for 12 weeks, to patients (n=268) with high-density lipoprotein (HDL) cholesterol <1.16 mmol/L. Fasting lipids/apolipoproteins (apos), insulin, glucose, and free fatty acid were measured; changes from baseline were calculated and assessed.
GW-501516 demonstrated HDL cholesterol increases up to 16.9% (10 mg) and apoA-I increases up to 6.6%. Reductions were observed in low-density lipoprotein (LDL) cholesterol (-7.3%), triglycerides (-16.9%), apoB (-14.9%), and free fatty acids (-19.4%). [R]
A second smaller exploratory study assessed GW-501516’s impact on lipoprotein particle concentration. Significant reductions in the concentration of very low LDL (-19%), intermediate LDL (-52%), and LDL (-14%) were observed, whereas the number of HDL particles increased by 10%.
Cardarine and Fatty Acids
A small study was conducted on mice to assess the impact of PPAR delta agonists on fatty acids. It was found that GW-501516 treatment induced fatty acid oxidation in mouse skeletal muscles.
Aside from that, Cardarine treatment also markedly improved diabetes. This was revealed by the decrease in plasma glucose and blood insulin levels in obese mice. These data suggest that GW-501516 merits further investigation for its potential ability to induce fatty acid oxidation. [R]
Cardarine and Running Endurance
A study was carried out to assess the impact of GW-501516 on running endurance in Kunming mice.
It was observed that this research compound enhanced running endurance in both trained and untrained mice. GW-501516 treatment also increased the percentage of slow-twitch muscle fibers. [R]
Cardarine and Inflammation
A recent study set out to investigate the effects of GW-501516 as a PPAR delta agonist on inflammation in mice. It was found that GW-501516 treatment reduced atherosclerotic lesions. This data shows that Cardarine merits further investigation as a potential treatment for atherosclerosis. [R]
To further assess its anti-inflammatory activity, one study examined interleukin-6 levels, which we know to be a marker of inflammation. The results obtained showed that GW-501516 might be useful for suppressing specific systemic inflammatory reactions. [R]
Cardarine and Metabolism
A study investigated the effects of GW-501516 administration on metabolic disorders in Caucasian men (ages 18 – 15). It was observed that a two-week treatment with GW-501516 ameliorated multiple metabolic abnormalities, including obesity, insulin resistance, and oxidative stress. [R]
Longer randomized trials and research could potentially evaluate its efficacy in improving physical function and health outcomes in select populations.
Cardarine FAQs
Is Cardarine A SARM?
Cardarine is not a selective androgen receptor modulator or SARM. SARMs work by binding androgen receptors in specific tissues, whereas GW-501516 specifically targets the peroxisome-activated receptor δ (PPARδ).
Is Cardarine Legal?
Cardarine is legal to buy and sell as a research compound. It can be used for laboratory research purposes only.
What Is The Half-Life of Cardarine?
Cardarine has a half-life of between 12 and 24 hours.
Does GW-501516 Increase Muscle Gene Expression?
Research has shown that Cardarine increases muscle gene expression, especially genes involved in preferential lipid utilization. This highlights its potential ability to enhance the cholesterol profile.
Where to Buy GW-501516 Online
Pure Rawz is the best place to buy Cardarine online.
In order to be the best SARMs supplier, we provide reference materials with every product we sell. Each of our SARMS comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.
We offer free worldwide shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.
Summary
Cardarine has demonstrated its ability to reduce inflammation, cause fatty acid oxidation, and improve cholesterol profile in animal studies. Long-term and randomized clinical trials are needed to evaluate its safety and efficacy in humans.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase, based on your own personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
By completing and paying for your order, you agree to our Terms and Conditions. Customer satisfaction is our number one priority, if you are not 100% satisfied with the product you received, please contact us at support@purerawz.co
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.
Wesley Riles –
Loving it. The results are quick and real.
Wesley R –
Super efficient for cutting.
Jonathan Manley –
This product delivers 100%! Very impressed.
Fredrick McGuire –
Great costumer support.
Mason Robinson –
Got the tabs and I must say they are a super convenient way to see great results.
Mitchell Nel –
Getting the summer body back!
Keith Yarrow –
100% satisfied.
Marc Finch –
Real results – very happy.
Kingsley Evers –
Highly recommendable.
Jason F –
One of the best quality cardarines
Ayrton Galagher –
The shreds are incredible!
Mike Kastins –
Really upped my endurance. Fantastic product.
Adrian R –
Quick results that you can most definitely notice.
Gordon Westerman –
Outstanding quality, real results.
Chris E –
Fast fat loss and endurance gain
Eric Wilson –
Better heart health. Doctor is amazed.
Innes White –
Burning lots of calories quickly.
jschristmas –
Really good product to increase endurance and help lose fat. I can tell a difference when I take this in my overall performance and stamina. A must for any cutting cycle or event prep.
Julian Nixon –
Noticeable improvement in my cardio at the gym when I use this.
Martin Scott –
This stuff is amazing, helped me get back in shape fast.
Daniel Brown (verified owner) –
Love this product! I can not believe the over all good feeling I get when taking it. And no matter how hard I work out I don’t get sore~
Joe K –
Great results!
Ben Whitehead –
Excellent product , great results in a short time
Charlie Edwards –
I am unstoppable thanks to your quality product! I recommended your website to some of my friends