Description

Purerawz GW-0742 + SR-9011 Stack

What is GW-0742 + SR-9011 Stack?

The potent research compounds GW-0742, a selective agonist for the peroxisome proliferator-activated receptor delta (PPARδ), and SR-9011, a synthetic agonist of the REV-ERB nuclear receptor, are combined in the GW-0742 + SR-9011 Stack. This unique combination is being explored for its potential synergistic effects on metabolism and circadian rhythms. GW-0742 may improve muscular metabolism, fatty acid oxidation, and endurance by influencing the expression of genes linked to the immune system, inflammation, and metabolism.

The stack may provide cumulative benefits when combined with SR-9011, which regulates the body’s rhythms in activity and metabolism. The interaction between PPARδ activation and REV-ERB modulation could lead to improved energy expenditure, better weight management, and enhanced metabolic responses. This combination makes it possible to research sleep disorders and metabolic health from a more complete angle.

Product information :

Purerawz GW-0742 + SR-9011 Stack contains a blend of GW-0742 and SR-9011. Available in tablet, capsule, and Injectablesa forms:

• Tablets: 20 mg per tablet (10 mg GW-0742 and 10 mg SR-9011). Available in 27 tablets (540 mg) and 54 tablets (1080 mg).
• Capsules: 20 mg per capsule ( 10 mg GW-0742 and 10 mg SR-9011). Available in 60 capsules (1200 mg).
• Injectabless: 70 mg per ml (35 mg GW-0742 and 35 mg SR-9011), totaling 700 mg in a 10 ml bottle.

GW0742

CAS number	317318-84-6
Molar Mass	471.5 g/mol
Chemical Formula	C21H17F4NO3S2
IUPAC Name	2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid

What is GW0742?

In 2003, GlaxoSmithKline created GW0742, a substance that functions as a specific agonist for the peroxisome proliferator-activated receptor delta (PPARδ) [R].

Various studies have examined its potential function in hypertension, diabetes, inflammation, obesity, and cancer. The dual nature of GW0742 makes it a PPAR agonist at low concentrations and an antagonist at high concentrations [R].

How does GW0742 work?

GW0742 has been shown to interact with nuclear receptors, influencing gene expression. It blocks the vitamin D receptor (VDR)-coactivator protein link, which turns on genes. This inhibits VDR target genes like IGFBP-3 and TRPV6, which are involved in cell differentiation and other activities. At higher concentrations, GW0742 acts as an antagonist, disrupting gene transcription regulated by VDR and other nuclear receptors. [R].

GW0742 also activates gene transcription at lower dosages but blocks it at larger doses with peroxisome proliferator-activated receptors (PPARs). Because it interacts with multiple receptor binding sites, it is important for researching cancer and metabolism gene regulatory scenarios [R].

GW0742 may :

• It may help treat a variety of inflammatory diseases and protect the lungs from lung cancer. [R][R][R]
• It may help manage weight by increasing insulin sensitivity [R]
• It may lead to a reduction in body mass. [R] [R].
• It may boost running and endurance performance [R].
• It may enhance immune function by increasing regulatory T cells. [R]
• It may improve muscle by boosting skeletal muscle oxidative capacity. [R]
• It may demonstrate the potential to protect astrocytes. [R]

SR-9011

CAS number	1379686-29-9
Molar Mass	479.0 g/mol
Chemical Formula	C23H31ClN4O3S
IUPAC Name	3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]-N-pentylpyrrolidine-1-carboxamide

What is SR9011?

SR-9011 is a compound under investigation that functions as an agonist for REV-ERB. To improve the original chemical, it was synthesized with SR9009 using GSK4112. The activity of receptor-related repressors is increased in a dose-dependent manner by both SR-9011 and SR9009. These substances have been shown to affect circadian rhythms, e.g., by postponing the onset of activity and shortening the duration of activity under specific circumstances. Studies carried out in research settings have shown that SR-9011 may aid in the development of remedies for diseases such as metabolic difficulties, sleep disorders, and others through its interaction with circadian proteins. Although SR-9011 has improved upon its predecessor’s features, more studies suggest that refinement is still necessary to obtain higher potency and selectivity [R].

How do SR-9011 capsules work?

SR-9011 increases receptor activation, altering energy use. SR-9011 may boost energy expenditure and fat loss, which could benefit metabolic illness research. The potential influence on muscular energy utilization is noteworthy, as it also enhances endurance and mitochondrial function during physical activity. [R]

The study suggests it may affect sleep and emotions. The capacity to reduce sleep and increase awake could advance sleep research. Although metabolic pathways and circadian rhythms are still being explored, SR-9011 must be given at greater dosages to produce positive results in tests. [R]

SR-9011 may help in:

• It may potentially help suppress cellular proliferation, such as cancer. [R][R][R]
• It may reduce body weight in mice subjected to diet-induced obesity. [R]
• It has the potential to help with dyslipidemia and hyperglycemia. [R][R]
• It has the potential to enhance cholesterol levels and regulate blood sugar. [R]
• It may help treat neuroinflammatory diseases.[R]
• It has the potential to enhance the immune system’s response. [R]

FREQUENTLY ASKED QUESTIONS

Where Can I Get the Best Products for GW-0742 + SR-9011 Stack?

PureRawz is a leading source of GW-0742 + SR-9011 Stack for sale. We get our raw ingredients from high-quality sources. Our chemicals have independent, third-party Certificates of Analysis for purity identification. Our product page also contains product descriptions that can be useful for research. Is your research looking for affordable alternatives and profound individual effects? You may opt to consider GW-0742 and SR-9011. PureRawz also offers a variety of other research chemicals, including PPARδ agonists, Ostarine, Peptides, and Cardarine SARMs, all of which may aid in weight loss research. Additionally, we provide supplements and other research chemicals in liquid forms for convenient use in research.

We offer free, fast shipping on cart orders over $100 in the US and abroad! This makes us the top option for the best GW-0742 + SR-9011 stack near you. Payment can be made by PayPal or Bitcoin. Click customer reviews to read what people think about our products and great prices.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with the appropriate IRB oversight. All preclinical research must be conducted with IACUC following the AWA guidelines.

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