What is Nicotinamide Riboside?

Nicotinamide riboside, also known as niagen, is a type of vitamin B3 (niacin). It is a known precursor of nicotinamide adenine dinucleotide (NAD+).

Other known precursors are nicotinamide and nicotinic acid.

Like other forms of vitamin B3, Nicotinamide riboside is converted by the human body into NAD+, a coenzyme or helper molecule.

The value of nicotinamide riboside NR stems less from what it does and more from what it enables others to do. It fuels other molecules, such as sirtuins, which play essential roles in the metabolic and immune systems.

Nicotinamide riboside NR is a distinct form of vitamin B3 that operates in the cell to support a variety of critical cellular processes. [R] [R] It has been shown to stimulate the following biological processes:

• Healthy Aging
• Cellular energy production
• Brain activity
• Liver health
• Metabolism in cells

The problem is that, through aging, levels of NAD+ naturally decline, which gives the likes of sirtuins less fuel to power their operations. [R]

Lower NAD+ levels decrease sirtuin activity, resulting in a slower metabolism and lower immunity. It can lead to various health issues, including obesity, heart disease, and cancer.

Nicotinamide riboside that is commercially produced is approved for research purposes only.

Even though it is a highly researched best-seller chemical, NR supplement still needs large-scale clinical studies before it is approved for human consumption.

Nicotinamide Riboside Research

It is critical to recognize that the majority of research on nicotinamide riboside and NAD+ is based on animal studies. As a result, no firm conclusions can be drawn about its efficacy in humans, even though it may promote healthy cellular metabolism.

Having said that, here are some potential nicotinamide riboside health applications.

Nicotinamide Riboside and NAD+

While it is necessary for cellular health, studies show that NAD+ levels decline as people age. Low NAD+ levels have been linked to premature aging and several harmful diseases. [R] [R]

Consuming NAD+ precursors – the building blocks of NAD+ – such as nicotinamide riboside is one way to boost NAD+ levels at the cellular level.

Data from animal studies demonstrate that nicotinamide riboside raises blood NAD+ levels by up to 2.7 times.

Furthermore, it is more easily absorbed by the body than other NAD+ precursors we know today. [R]

Nicotinamide Riboside and Brain Health

Some preliminary research indicates that nicotinamide riboside supplement may protect neurons. Nicotinamide riboside use was linked to fewer cognitive deficits, lower beta-amyloid plaque production, lower tau tangle levels, and fewer living cell deaths. [R]

It may also contribute to the growth and development of neural tissue and the cellular function of neural stem cells in older mammals. [R] Lab tests involving mice prove this.

Increasing NAD+ levels with nicotinamide riboside or other methods appears to protect the brain and improve aging-related disorders like metabolic disease and diabetes, both risk factors for cognitive diseases. [R]

Despite the fact that ten clinical trials are currently underway, no studies have confirmed the benefits of nicotinamide riboside in humans.

Nicotinamide Riboside and Healthy Aging

Nicotinamide riboside (NR) is a molecule that is essential for cellular health. NAD+ (nicotinamide adenine dinucleotide) is required for over 500 biochemical reactions in the human body.

Nicotinamide riboside aids in the increase of NAD+ levels in the body. As a result, NAD+ activates enzymes that may promote healthy aging.

Sirtuins, for example, appear to improve animal longevity and overall health. According to research, sirtuins may repair damaged DNA, increase stress resistance, reduce inflammation, and provide other benefits that promote healthy aging. [R] [R]

Nicotinamide Riboside and Heart Well-being

Aging has a significant impact on heart vitality and performance. It can cause blood vessels, such as your aorta, to thicken, stiffen, and become less flexible.

According to one animal study, increasing NAD+ helped reverse age-related vascular changes.

In another study, NR’s increasing NAD+ levels helped reduce aortic stiffness and lower systolic blood pressure among adult mammals at risk of high blood pressure.

However, more human research is required on the potential applications of nicotinamide riboside.

Nicotinamide Riboside and Jet Lag

Changes in NAD+ levels may be the root cause of jet lag and overall energy loss associated with aging.

As a result, by increasing NAD+ levels, the body may be able to regulate its internal clock. This could imply that niagen, resetting the body’s internal clock, can help treat jet lag and other circadian rhythm disorders. [R]

Nicotinamide Riboside and Weight Management

In one study, nicotinamide riboside has shown an ability that could address weight issues.

This chemical helped speed up the metabolism of mice. However, it is still not proven whether it would have the same effect on humans or how effective this benefit could be. [R]

Nicotinamide Riboside and Muscle Aging

Raising NAD+ levels helped older mice improve their muscle function, strength, and endurance. This could imply that NR improves exercise performance by increasing muscular energy levels. [R] [R]

How does Nicotinamide Riboside Work?

Nicotinamide riboside (NR) is a vitamin B3 compound. Like other forms of vitamin B3, Nicotinamide riboside is converted into nicotinamide adenine dinucleotide (NAD+), a coenzyme required for life.

An important role of NR is to act as an intermediary, converting itself into NAD+ and providing fuel to the cells so they can continue to function. NR is one of four ways the body can produce NAD+.

Safety and Side Effects of Nicotinamide Riboside

During several research trials, there were no reports of serious adverse effects from NR. Mild side effects have been reported on occasion, including: [R]

• Nausea
• Muscle aches and cramps
• The bruising has increased.
• Blood pressure becomes high

A 300-mg dose per kg of body weight (136 mg per pound) daily for 90 days had no negative effects on animals. [R] This dosage, however, is not recommended for humans since NR is still a research chemical that must be purchased solely for research purposes.

Frequently Asked Questions

What is nicotinamide adenine dinucleotide?

Nicotinamide adenine dinucleotide (NAD+) is a naturally occurring nucleotide that plays an essential role in the body’s energy production.

Is nicotinamide riboside safe for human usage?

The FDA does not deem nicotinamide riboside as safe for general human consumption. To date, this is still an experimental chemical that needs further studying.

What other research chemicals can you combined-formula with nicotinamide riboside?

NR can be safely combined-formulaed and researched with pterostilbene and trans resveratrol.

Where can you buy Nicotinamide Riboside?

PureRawz is an online site that is the best place to buy nicotinamide riboside. You can visit our website to order and check out nicotinamide riboside.

To be the best research chemicals supplier, we provide our customers with reference materials for every product we sell. Each product comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.