Laxogenin (5a-Hydroxy Laxogenin) – Product Information
5-alpha-hydroxy laxogenin, or laxogenin for short, is a non-hormonal steroid. Researchers refer to it as the ‘plant steroid’ because it belongs to a class of plant hormones called brassinosteroids, whose structure is similar to animal steroid hormones.
It is posited to have the ability to enhance muscle growth and recovery by inhibiting the stress hormone cortisol. Preliminary studies also point to the possible effect it can have on the increase of protein synthesis while reducing protein breakdown.
What Is Laxogenin?
Laxogenin is a plant-based steroid. It helps the plants to grow.
Laxogenin is derived from brassinosteroids. Brassinosteroids are a group of plant hormones that have been shown to increase protein synthesis and decrease protein degradation in cell culture. This explains why laxogenin is known as a plant anabolic. [R]
In a recent study, a specific type of brassinosteroid produced a stimulatory effect on protein synthesis in muscle cells. This led to increases in lean body mass, muscle mass, and physical performance. This shows that Laxogenin holds great potential as an anabolic agent. [R]
How Does 5a-Hydroxy Laxogenin Work?
Plant steroids like Laxogenin have a completely different working mechanism than their human counterparts. Studies have shown that they only bind the cell surface, setting off a signal to the inside of the cell to increase muscle building. [R]
They do that by activating a protein known as AKT1 or protein kinase B. AKT1 has been proven to prevent the breakdown of muscle proteins and enhance muscle building. In a genetic model, AKT1 hypertrophic muscles also showed increased strength. [R] [R]
In a separate study, natural laxogenin derivatives inhibited the enzyme that breaks down cAMP (phosphodiesterase). This leads to an increase in cAMP levels, boosting fat breakdown and activating sympathetic (fight-or-flight) response. [R] [R]
No clinical studies have been conducted on laxogenin to date. Only animal and cell-based research substantiates the potential effects of this plant-based steroid. But they should only guide further investigational efforts and shouldn’t be interpreted as backing any health benefit.
Laxogenin and Lean Muscle Growth
In an old Russian study, rats were fed a type of brassinosteroid with a similar structure to Laxogenin. The research found that the compound increases the total weight and protein content of the leg muscles, liver, heart, and kidneys without raising sex hormones. [R]
Oral administration of another brassinosteroid increased food intake, body weight gain, lean muscle mass, and gastrocnemius muscle mass as compared with vehicle-treated controls. Moreover, brassinosteroid treatment was associated with improved physical fitness. [R]
In another study, the effects of brassinosteroid and its synthetic derivatives were measured on the skeletal muscle mass of rats. It was found that both compounds promoted protein production. They also reduced protein degradation in muscle cells. [R]
Laxogenin and Blood Sugar
A study was conducted to determine the hypoglycemic effects of homobassinolide (a type of brassinosteroid) on healthy mice. It was reported that the oral administration of HB triggered a selective anabolic response that was associated with lower blood glucose. [R]
Similarly, another study set out to evaluate the effects of HB administration on glucose metabolism, insulin sensitivity, body composition, and more. It was found that acute oral administration of 50 – 300mg/kg of HB to obese mice resulted in a dose-dependent decrease in fasting blood glucose. [R]
These results indicate the potential anti-diabetic effects of brassinosteroids.
Laxogenin and Cancer
Laxogenin was proven to have an antitumor-promoting activity in a two-stage lung carcinogenesis experiment. In two separate studies, natural and synthetic laxogenin derivatives were found to kill leukemia and colon cancer cells. [R] [R] [R]
However, in the absence of randomized, long-term clinical trials, more studies on select populations are needed to substantiate the effects of Laxogenin on cancer.
Laxogenin and Fat Breakdown
In a study, natural laxogenin derivatives blocked the enzyme that breaks down cAMP (phosphodiesterase). This inevitably leads to an increase in cAMP levels as the enzyme inhibiting its production has been blocked. [R]
Various studies have shown that an increase in cAMP levels increases lipolysis. Lipolysis is the process by which fats break down and release in the form of fatty acids. The cAMP has been found to increase lipolysis by binding and activating protein kinase A (PKA). [R]
Still, more evidence is needed to definitively link Laxogenin with fat loss.
Laxogenin and Tissue Damage
In a cell study, a natural laxogenin derivative prevented free radicals and poor oxygen supply from causing tissue damage. This shows massive promise in the potential ability of Laxogenin to neutralize oxidative stress. Still, human and animal studies are needed. [R]
Where to buy Laxogenin Online?
PureRawz is the best place to buy Laxogenin for sale.
In order to be the best SARMs supplier, we provide reference materials with every product we sell. Each of our SARMS comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.
Is Laxogenin Safe?
No adverse events have been reported in the multiple animal and cell-based studies conducted to date. Still, to confirm its safety, large-scale clinical trials are needed.
Is Laxogenin Natural?
Yes. Laxogenin is derived from the underground stems of the Asian plant Smilax sieboldii. The plant contains approximately 0.06% laxogenin which is its chief natural source. Laxogenin can also be obtained from Chinese onion bulbs or Allium Chinense.
Is Laxogenin Legal?
Laxogenin is legal to buy and sell as a research compound.
What Are the Side Effects of Laxogenin?
There isn’t enough scientific evidence to know if laxogenin is safe for the elderly, and pregnant or breastfeeding women. Such people are thus recommended to avoid use.
Multiple animal and cell-based studies have shown that Laxogenin possesses anabolic, anti-diabetic, and antioxidant properties. If you’re looking for safe, effective, and pure Laxogenin for sale, you cannot go wrong with Pure Rawz.